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Heptode Mini Matrix

Neuroscience Products > Accessories > Amplifiers > Data Acquisition Systems > Eye Tracking Systems > Microdrives > Microelectrodes > Microinjection Systems> Optogenetic Products > Primate Training Systems > Screws > Software > Stereotaxic Instruments > Rodent Products Electrochemical Products

Heptode Mini Matrix

The Thomas Heptode Mini Matrix (HMM) is a software controlled motorized microdrive with patented driving principle and up to 32 recording channels. The Heptode Mini Matrix moves up to 4 heptodes (7 channel fiber microelectrode, outer diameter 100 µm) and 1 tetrode (4 channel fiber microelectrode, outer diameter 100 µm) independently from each other to different depths of the brain. With a travel distance of up to 24 mm (larger travel distances on request) this allows cortical as well as deep brain recordings. One can replace a tetrode or heptode by an injection pipette, an optical fiber or an electrical stimulation electrode and move it like the heptodes/tetrodes, computer controlled into the brain.

Key features:

  • 5 micromotors move 5 probes independently from each other
  • Electrode travel distance: up to 24 mm
  • Up to 32 recording channels
  • Axial resolution better than 1µm
  • Recording with up to 32 recording channels
  • Electrical stimulation with IrOx coated fiber stimulation electrodes
  • Microinjection with fiber (metal or glass) injection cannulas
  • Optical stimulation with optical fibers
  • Axial resolution better than 1µm
  • High precision & quality “Made in GERMANY” by Thomas RECORDING
  • Variable speed range 0…250 µm/s, higher velocity on request
  • Custom-made solutions for each recording application for NHP or rodents
  • Networkable motor control unit (LAN communication via TCP/IP)
  • Xyz manipulator for reproducible recording position
  • Integrated motor control and data acquisition-software
  • HeptodeMiniMatrix Webseite Bilder 008
Technical Data
Features
Downloads

Electrode travel:

Up to 24.000 µm

Resolution:

1µm in z-axis, x- and y-axis with a grid in primate recording chambers, or xy-manipulator in small animal stereotaxy

Electrodes:

Quartz glass insulated platinum tungsten microelectrodes (OD=80-100µm), single electrodes, tetrodes (4 metal cores) and heptodes (7 metal cores)

Number of electrodes

Up to 5 individual fibers (e.g. electrodes, tetrodes, heptodes, optical fibers, injection cannulas) independently moveable to different depths of the brain

Preamplifier:

32 channels (integrated in the Microdrive chassis to avoid electrical interference pickup from the lab environment

Multicontact Probes:

TREC tetrodes and heptodes

Motor Control:

8 channel Microprocessor motor control unit

Remote Control:

Wireless/wired handheld remote control (tablet, standard), wired handheld remote control (optional available)

Chamber Clamp:

customized to the user’s recording chambers (e.g. Crist chambers)

Dimensions

see drawing below for standard Mini Matrix configuration

HeptodeMiniMatrix Webseite Bilder Measures

ORDERING INFORMATION

Primate setup (standard)

Qty.

Article number

Description

1

AN001673

Heptode Mini Matrix Microdrive

1

AN000165

Xyz-manipulator

1

AN000389

Motor control unit (MCU-2) with handheld remote control and external power supply

1

AN001722

128 Channel Digital Recording System (DRS-C128) Controller

1

AN001647

Software license for a Heptode Mini Matrix system

   

Small Animal Setup (standard)

Qty.

Article number

Description

1

AN001673

Heptode Mini Matrix Microdrive

1

AN000977

Rod-adapter for mounting the Thomas Matrix Drive to a small animal stereotaxic instrument

1

AN000389

Motor control unit (MCU-2) with handheld remote control and external power supply

1

AN001722

128 Channel Digital Recording System (DRS-C128) Controller

1

AN001647

Software license for a Heptode Mini Matrix system

The new Heptode Mini Matrix is available for research applications with rodents or non-human primates. The Microdrive allows to move up to five fibers (single electrodes, tetrodes, heptodes, optical fibers, injection cannulas, stimulation electrodes) independently from each other to different depths of the brain. The electrode travel distance is up to 24.000 µm. A 32-channel low-noise preamplifier is integrated in the microdrive chassis. As the chassis is made of anodized aluminum it is working like a Faraday cage, shielding the recording electrodes from electrical interference. The Microdrive can be easily adapted to different stereotaxic setups e.g., for rodents and non-human primates (see figure 1).

HeptodeMiniMatrix Webseite Bilder Fig1
Figure 1a: Heptode Mini Matrix with xyz-manipulator mounted to an implanted recording chamber for NHP applications. A LED light source for optogenetic applications is installed on side of the microdrive chassis and an optical fiber is loaded to the Microdrive. This unit is optional available.
HeptodeMiniMatrix Webseite Bilder Fig2
Figure 1b: Heptode Mini Matrix with a rod adapter for use with a standard rodent stereotaxic instrument. A LED light source for optogenetic applications is installed on side of the microdrive chassis and an optical fiber is loaded to the Microdrive. This unit is optional available.
HeptodeMiniMatrix Webseite Bilder Fig2
Figure 2: Heptode Mini Matrix with four heptodes (7 core microelectrodes) and one optical fiber loaded to the microdrive chassis.

 

The Heptode Mini Matrix components are shown in figure 2. The Microdrive head is exchangeable to realize different electrode arrangements (e.g. linear, concentric) with different electrode spacing (e.g. 80µm, 300µm, etc.). The Microdrive is able to record from up to 32 recording channels (if 4 heptodes and 1 tetrode is loaded to the microdrive). If the tetrode is replaced

  • by an injection cannula, one can inject drugs
  • by an optical fiber, one can stimulate neurons by light
  • by a stimulation electrode, one can electrically stimulate neurons

and record the neural response with the reaming four heptodes (28 recording channels).

The used fiber microelectrodes have outer diameters of 80-100 µm, causing only minimal tissue damage when introduced in the recording target. In histological preparation one can hardly see the electrodes trajectories!

HeptodeMiniMatrix Webseite Bilder Fig3
Figure 3: Heptode Mini Matrix motor control setup. Each of the 5 motrors of the Heptode Mini Matrix is controlled by a microprocessor motor control unit (MCU-2) and a control software running on e personal computer under Microsoft© Windows© operating system. The system is delivered with a computer tablet based handheld remote-control unit.

 

Figure 3 shows the Heptode Mini Matrix Microdrive connected to a motor control unit. The motor control unit has up to 8 channels so that it is possible to add further motorized devices like our motorized microinjection pumps. It is possible to control the microinjection pump with the same software that controls the Heptode Mini Matrix Motors.

 

HeptodeMiniMatrix Webseite Bilder Fig4
Figure 4: Block diagram of the Heptode Mini Matrix system for NHP applications. The system uses software that controls the micromotors of the Heptode Mini Matrix as well as the neural data acquisition. This has the advantage that one does not get synchronization problems between the electrode position and the neuronal signals recorded at one position. Both pieces of information are recorded synchronously in real time.

 

HeptodeMiniMatrix Webseite Bilder Fig5
Figure 5: Block diagram of the Heptode Mini Matrix system for rodent applications. The system uses software that controls the micromotors of the Heptode Mini Matrix as well as the neural data acquisition. This has the advantage that one does not get synchronization problems between the electrode position and the neuronal signals recorded at one position. Both pieces of information are recorded synchronously in real time.

 

Functional Connectomics with the Heptode Mini Matrix

The study of the “wiring diagram of the brain” on different scales is the focus of connectomics, a subfield of neuroscience. However, to understand information processing in a connectome, it is necessary to visualize the neural network in the brain area of interest in a living organism in real time. This is not yet possible with currently available brain research methods. The Thomas Heptode Mini Matrix together with a new 3D-reconstruction software demonstrates a new technique for the 3D-reconstruction of the position of active neurons in a neural network. The technique uses extracellular recordings with our Heptode Mini Matrix loaded with our multichannel microelectrodes (e.g., tetrodes or heptodes) and postprocessing of the recorded data by a special developed software. The principle is shown in figure 5. The 3D-reconstruction software is optionally available for the Heptode Mini Matrix system.

HeptodeMiniMatrix Webseite Bilder Fig6
Figure 6: Heptode Mini Matrix used together with our 3D-Recontruction software for functional connectome studies

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